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학술발표회초록보기

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  • 09월 10일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Concanavalin A and structural features through metal coordination

등록일
2019년 8월 28일 10시 20분 20초
접수번호
1671
발표코드
INOR.P-102 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 17일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Inorganic Chemistry
저자 및
공동저자
Hara Jang, Seung Jae Lee*
Department of Chemistry and Institute for Molecular Biology and Genetics, Chonbuk National University, Korea
The structure and functions of ConA have been intensively studied for its potential contribution to defense mechanisms through interaction with carbohydrates, glycoproteins, metabolites, and signaling molecules from diverse organisms, including microorganisms. Biophysical studies on ConA and pathogen glycoproteins have provided details on their interactions for the field of diagnostic microbiology, and these studies can be extended for detecting and estimating the concentration of viruses. Studies on the structure of ConA from Canavalia ensiformis, the jack bean, have demonstrated crucial details, including interaction residues such as hydrogen bonds and salt-bridges with carbohydrates. Reports have shown that heterometal ions, including manganese and calcium ions, are crucial for this interaction with carbohydrates. These metal ions and coordinated residues are located near the loop of carbohydrate interaction residues. Most reported structures were crystallized as complexes, including dimers and tetramers, which could affect the interaction with their binding partners, as sidechains and backbones for sugar binding can be shielded and their orientations may change based on complex formation. The binding affinity of ConA differs based on the buffer conditions, and these differences could be attributed to the formation of different complexes. The structural properties based on specific conditions for crystallization and the binding events of monomers to their binding partners, including microbial pathogens, still need to be elucidated

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