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제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Inhibition and dissociation effect of gold nanoparticles on amyloid fibrils induced by Near-IR laser irradiation

등록일
2019년 8월 28일 14시 21분 09초
접수번호
1690
발표코드
ANAL.P-157 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 18일 (금요일) 11:00~12:30
발표형식
포스터 분석구두발표
발표분야
Analytical Chemistry
저자 및
공동저자
Chae ri Park, Chae Eun Heo, MyungKook Son, Min Ji Kim, Sooyeon Chae, Paul Valery Migisha Ntwali, Hugh I. Kim*
Department of Chemistry, Korea University, Korea
Amyloid-β (Aβ) fibrils, which are self-assembled peptides of Aβ, have been regarded as pathogenic hallmarks in Alzheimer’s disease. To remove the amyloid fibrils, several studies have been tried to dissociate fibrils by physical stimulation such as NIR radiation nanoparticles. In these regards, some metal nanoparticles have been reported not only to inhibit amyloid fibril formation but also dissociate preformed fibrils with a photothermal effect under NIR light. However, it has not yet been revealed how fibril dissociation is affected by the size, shape, and ligand of nanoparticles and NIR laser power. Here, we have studied dissociation characteristic of amyloid fibril using star-shaped gold nanoparticles under NIR laser irradiation. First, we synthesized star-shaped gold nanoparticle with the size of 60nm. Then, after applying 1W 808nm NIR laser for several minutes, we found amyloid fibrils are partially disintegrated with these gold nanostars. In this process, we used thioflavin T (ThT) assay to monitor the formation of amyloid fibrils and identify the changed quantity of fibrils after laser irradiation. To identify the morphology and structural characteristics of amyloid fibrils, we used a transmission electron microscope (TEM), circular dichroism (CD), FT-IR spectrophotometer, etc. The results obtained from these analytical techniques will help us to search ideal characteristics of size and shape, ligands of nanoparticles, which act as a disrupter of amyloid fibrils.

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