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제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Unlocking the Mysteries of Amyloid Diseases with Macrocyclic β-Sheet Peptides & The Supramolecular Chemistry of the Antibiotic Teixobactin

2019년 8월 28일 14시 35분 26초
LIFE1-1 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 15시 : 40분
Life Chemistry - [Life Chemistry Division-Korean Peptide Protein Society Joint Symposium] Recent Trends in Peptide Chemistry
저자 및
James S. Nowick
Chemistry, University of California, Irvine, United States
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승인 1건

This presentation will cover two ongoing projects in my laboratory aimed at elucidating the structures and interactions of biologically relevant peptides. The first seeks to understand the supramolecular assemblies of the oligomers formed by the β-amyloid peptide Aβ in Alzheimer’s disease. The second seeks to better understand how the antibiotic teixobactin achieves its remarkable activity against Gram-positive pathogens. In the amyloid project, we have constructed a series of conformationally constrained peptides derived from Aβ and elucidated their oligomeric assemblies by X-ray crystallography. We have then generated antibodies against these assemblies and identified features in the brains from transgenic mouse models for Alzheimer’s disease that react with these antibodies. In the teixobactin project, we have discovered that amyloid-like assembly of teixobactin-derived peptides generates receptors for anions, and we have provided a working model for how teixobactin binds lipid II and related cell wall precursors. Recent results and ongoing studies in both of these projects will be presented.