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  • 09월 10일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Can the aqueous microdroplets work as reaction vessels for the building block of primitive lifeforms?

2019년 8월 28일 16시 24분 42초
LIFE.P-226 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 18일 (금요일) 11:00~12:30
Life Chemistry
저자 및
Hani Jeon, Sangmoon Lhee*
Center for Plant Aging Research, Institute for Basic Science, Korea
The micron-sized aqueous microdroplet provides peculiar physico-chemical environments enabling the accelerated reaction rates and modulating the thermodynamic values of reaction components. Although abiotic sugar phosphates and nucleosides synthesis are unfavorable in the bulk solution, such the reactions became favorable under the microdroplet environment, suggesting the microdroplet like cloud particles can work as synthesis reaction vessels for some biological materials. Here, we have tested the chain elongation of nucleotides and protein based on the microdroplet system. The elongation processes of DNA/RNA and protein chains are based on the condensation reactions of monomeric building blocks such as nucleotides and amino acids, which are exergonic (unfavorable) in aqueous solution. So, we observed the procedure of such the reactions in the form of the microdroplet. The elongation reactions of nucleotides and amino acids in the charged microdroplet is verified by high-resolution mass spectrometry. We expect that we can show a plausible physico-environment bearing the basic building blocks of primitive lifeforms through the microdroplet studies. Furthermore, these studies provide ultimate information about many biological reactions relating the aging processes of plants and animals, which happen inside the confined space like microdroplet. Keywords: Microdroplet, Electrospray ionization, Prebiotic chemistry