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제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Quantitative study of mammalian gene expression based on chromatin looping structure

등록일
2019년 8월 28일 16시 25분 51초
접수번호
1725
발표코드
PHYS.P-206 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 17일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Physical Chemistry
저자 및
공동저자
Jaehyuk Won, Ji-Hyun Kim*, Jaeyoung Sung*
Department of Chemistry, Chung-Ang University, Korea
In mammalian cells, actively transcribed genes are organized to be in close proximity to each other, forming transcriptional interactome. For genes belonging to an interactome, their expressions are highly correlated in a positive sense. In addition, it has been recently found that transient or stable aggregates of RNA polymerase (RNAP) II molecules are formed around such interactomes. Understanding how mammalian gene expression is influenced by such factors Is still missing. In order to provide an analytical framework targeting this problem, we present the mammalian gene expression model with RNAP II cluster dynamics and gene activity fluctuation taken into account. From the RNA-sequence experimental data over five human breast cancer cell lines, we could extract the correlation-noise relationship for genes transcribed through basal promoters and multi-gene interactomes. It is shown that the present theory can make a quantitative prediction to the experimental result in conjunction with three different degradation models

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