초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 09월 10일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Chirality Amplification in Water Cages

2019년 8월 28일 16시 55분 22초
ORGN.P-425 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 18일 (금요일) 11:00~12:30
Organic Chemistry
저자 및
Choong eui Song*, Si Joon Park, InSoo Hwang, Han Yong Bae1, Jiyoon Jung
Department of Chemistry, Sungkyunkwan University, Korea
1Department of Chemistry, UNIST, Korea

Homochirality is a fundamental component of molecular recognition in biological systems. Most theories for biological homochirality require a chiral amplification mechanism that acts to enhance a small initial asymmetry. We have found that water can induce the chirality amplification in a catalytic asymmetric reaction. Under on-water conditions, the enantioselectivity of a catalytic reaction can be significantly enhanced in the confined hydrophobic spaces of organic droplets surrounded by water. More significantly, this chirality amplification can be further increased by decreasing the droplet size. The droplet size effect on the enantioselectivity was quantified by using the biphasic microfluidic technique. Although in-depth mechanistic studies are still needed in order to fully understand the role of water, we can conclude that this water-induced chirality amplification can be attributed to the hydrophobically induced confinement effect. This remarkable observation could provide some inspiration for developing new strategies to enhance enantioselectivity and thus has the potential to open a new chapter in the field of asymmetric catalysis. In addition, our discovery that the enantioselectivity can be greatly amplified in the confined cavities of water cages could help unlock secrets of homochirality which is a fundamental component of molecular recognition in biological systems.