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  • 09월 10일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Sequestering ATP inside Mitochondria by Nucleopeptide inducing Cancer Cell death

등록일
2019년 8월 28일 17시 28분 58초
접수번호
1734
발표코드
LIFE.O-2 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 09시 : 15분
발표형식
구두발표
발표분야
Life Chemistry - Oral Presentations by Young Life Chemists
저자 및
공동저자
Huyeon Choi, Ja-Hyoung Ryu1,*
Ulsan National Institute of Science and Technology, Korea
1Department of Chemistry, Ulsan National Institute of Science and Technology, Korea
Adenosine triphosphate (ATP) has important roles in cellular processes such as energy production, cellular respiration, cell signaling and metabolism. Most of cancer cells have three times higher concentration of ATP compared to normal cells. By removing ATP inside cancer cells, it can result in severe effect such as apoptosis. Herein, we developed selective cancer treatment by sequestration and self-assemblies of ATP with nucleopeptide (NP). NP has nucleobase (thymine, thy) which interacts with adenine and alternative positively charged amino acids and hydrophobic amino acids which are mitochondria targeting sequence and it can self-assemble in water. NP exhibits higher binding affinity with ATP by electrostatic interaction and hydrogen bond resulting in large complex and assemblies with ATP compared to ADP. To enhance selectivity towards cancer cells, NP-ADP having nanometer-sized micelles accumulates inside cancer cells and form large assembly with ATP which has higher binding affinity by reversible interaction. Thus, sequestration of ATP and large assemblies of NP-ATP inside mitochondria cause severe effects such as the metabolic process of ATP and stress by structures towards cancer cells.

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