abs

학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 09월 10일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Highly Diastereo- and Enantioselective Catalytic Addition of 1,1-Diborylalkanes to Ketimines Using Copper(I)-Catalysis

등록일
2019년 8월 28일 23시 37분 26초
접수번호
1764
발표코드
ORGN.P-430 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 18일 (금요일) 11:00~12:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Jeongho Kim, Minkyeong Shin, Seung Hwan Cho*
Department of Chemistry, Pohang University of Science and Technology, Korea

Previously, we developed an efficient copper(I)-catalytic system for diastereo- and enantioselective 1,2-addition of 1,1-diborylalkanes to aldimines to afford chiral β-aminoboron compounds that can potentially be used to building blocks of synthetic chemistry. Therefore, We envisaged that the reaction of 1,1-diboryalkanes with ketimines would provide β-aminoboronate esters containing contiguous tetrasubstituted and trisubstituted stereocenters. However, this strategy is challenging because ketimines were knowns to be intrinsically less reactive than aldimines. Herein, we describe a broadly applicable copper catalytic conditions for the diastereo- and enantioselective 1,2-addition of 1,1-diborylalkanes to ketimines. Further transformations that convert the obtained β-aminoboronate esters to synthetically beneficial chiral building blocks are also demonstrated.


상단으로