abs

학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 09월 10일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Folding Ability of Telomeric Human G-quadruplex Structures: Using Fluctuating Thermodynamic Methods

등록일
2019년 8월 29일 11시 54분 41초
접수번호
1787
발표코드
PHYS.P-209 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 17일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Physical Chemistry
저자 및
공동저자
Minwoo Kim, Song-Ho Chong1, Seokmin Shin, Sihyun Ham1,*
Department of Chemistry, Seoul National University, Korea
1Department of Chemistry, Sookmyung Women's University, Korea

G-quadruplex is the DNA complex consisted of the telomere with ligands, which is located at the end of genomic sequences in chromosomes. Its genomic instability causes serious problems of transcription and translation, such as the production of cancer cells. In this study, we performed molecular dynamics simulations of microsecond time-scale for three types of telomeric human G-quadruplex (Tel22), called antiparallel, hybrid and parallel. Also, we computed thermodynamic parameters including conformational entropy by using fluctuating thermodynamic methods. We find that the hybrid type of G-quadruplex exhibits the highest conformational entropy among the three. Based on the conformational and thermodynamic analyses, we provide the molecular origin of the DNA thermodynamic instability and its consequence to the DNA folding ability.


상단으로