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학술발표회초록보기

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제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Photodynamic Therapy of Iridium complexes by Lysomal Protein Oxidation

등록일
2019년 8월 29일 12시 42분 50초
접수번호
1794
발표코드
ORGN.P-434 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 18일 (금요일) 11:00~12:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Mingyu Park, Tae-Hyuk Kwon1,*, Sungjin Park2, Taiho Park3
Chemistry, Ulsan National Institute of Science and Technology, Korea
1Eco-Friendly Energy Engineering, Ulsan National Institute of Science and Technology, Korea
2Chemical Engineering, Pohang University of Science and Technology, Korea
3Department of Chemical Engineering, Pohang University of Science and Technology, Korea
Efficacy of lysosome targeting iridium photodynamic therapy agent was studied followed by mass spectrometric proteome analysis. Iridium complexes with lysosome targeting morpholine moiety showed high biocompatibility under dark condition and effective cancer cell suppression via reactive oxygen species generation. Photophysical properties were analyzed and in vitro cell tests were done including MTT assay. Also, target motions of iridium series were investigated by confocal microscopy.

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