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제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Peptide-based surface-fill hydrogel facilitates miRNA delivery to treat mesothelioma

2019년 8월 29일 14시 06분 05초
LIFE1-3 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 17시 : 00분
Life Chemistry - [Life Chemistry Division-Korean Peptide Protein Society Joint Symposium] Recent Trends in Peptide Chemistry
저자 및
Poulami Majumder, Anand Singh1, Caroline Andrews2, Ziqiu Wang3, Kingshuk Dutta4, Nimit Patel5, Natalia De Val Alda3, Chuong D. Hoang1,*, Joel P. Schneider*
Chemical Biology Laboratory, National Cancer Institute, National Institutes of Health, United States
1Thoracic Surgery Branch, National Cancer Institute, National Institutes of Health, United States
2Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, United States
3Advanced Technology Research Facility, United States
4Department of Chemistry, University of Massachusetts Amherst, United States
5Small Animal Imaging Facility, Leidos Biomedical Research, Inc., United States
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승인 9건
Cancers, such as mesothelioma, that grow as sheets on the surface of organs and tissues having complex anatomical features represent a unique challenge in oncology. In contrast to solid tumor masses, their surgical resection often leaves residual cancer that causes rapid recurrence. We developed a peptide-based hydrogel that can be sprayed or injected to effectively cover large surface areas of organs and tissues having complex anatomical features, including those resulting from surgical resection. Once implanted, the material can shape-change to accommodate real-time changes in tissue morphology. The material locally delivers nanoparticles engineered from intrinsically disordered peptide and miRNA that effectively enter cells, escaping the acidic endosome to target mRNA important for the progression of mesothelioma, an aggressive asbestos-related cancer. Interestingly, endosomal release of the nanoparticles is dependent on the conformational state of the peptide comprising the particle-the peptide must be disordered. We show that with a single application, this gel produces a durable pre-clinical response in three increasingly complex models of mesothelioma. In principle, this regional treatment strategy could be applied to other surface cancers, including ovarian carcinoma and gliomas.