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제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 A Hollow 3D Architecture Formation by Self-assembly of Helical Peptide Mimetic with Poor Macrodipole

등록일
2019년 8월 29일 14시 32분 55초
접수번호
1821
발표코드
MAT.P-381 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 17일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Material Chemistry
저자 및
공동저자
Kim Jaewook, Jintaek Gong, Hee-Seung Lee*
Department of Chemistry, Korea Advanced Institute of Science and Technology, Korea

Foldectures, self-assembly of unnatural helical peptide, are well-defined 3D architectures with functional anisotropic surfaces which can serve as potential biochemical materials. Previous studies have shown that physical properties of helical peptides have a strong effect on synthesizing foldectures. However, it was hard to determine whether macrodipole, one of the most important property of helical peptide, is an important factor on foldecture formation. Here, we have synthesized a helical peptide mimetic, foldamer f1, which has similiar shape of helical peptide but having less macrodipole. Following a standard foldecture synthesis process, foldamer f1 self-assembled in a homogeneous foldecture F1 with a well-defined morphology. Powder X-ray diffraction pattern of foldecture F1 shows multiple sharp peaks which indicates clear packing structure and was used to solve molecular structure. Based on F1 structure, it is clear that macrodipole doesn’t affect on fast nucleation of foldecture but stable helical molecule having distinct intermolecular hydrogen bond system is the main key.


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