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  • 09월 11일 00시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Stimuli-responsive nano-therapeutics based on hyaluronic acid

2019년 8월 29일 14시 32분 47초
MEDI-2 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 16시 : 10분
Medicinal Chemistry - Innovative Therapeutics and Diagnostic Agents in Medicinal Chemistry
저자 및
Ki Young Choi*, Jae Hyung Park1
Natural Product Informatics Research Center, Korea Institute of Science and Technology, Korea
1Division of Chemical Engineering, Sungkyunkwan University, Korea
Stimuli-responsive drug delivery nanomaterials have gained much attention as intelligent therapeutic means for the treatment of diverse diseases given that they can prolong bioavailability of chemo-/bio-therapeutic agents and enable activation of their therapeutic or diagnostic functions at the target disease tissues. By securing both blood stability and stimuli-responsive activation, it is possible to improve therapeutic efficacy while reducing adverse toxicity to the normal tissues. HA is a naturally occurring polysaccharide; it is highly water-soluble, biocompatible and biodegradable. HA also has unique biological traits such as strong binding with cell surface receptors such as CD44 and catabolism by HA-degrading-enzyme, hyaluronidases, ROS or RNS. Given the desired biological properties of HA, we have been employed HA as a building block or surface coating materials for targeted, stimuli-responsive drug delivery systems. In this talk, recent advances in designing stimuli-responsive HA nanomaterials that we developed will be reviewed and their diagnostic and therapeutic potential will be discussed.