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제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis of Polymeric Drug Carrier Particles with Hierarchically Interconnected Nanopores using PLGA-PEI for Rapid Drug Delivery

2019년 8월 29일 14시 44분 51초
MAT.P-382 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 17일 (목요일) 11:00~12:30
Material Chemistry
저자 및
Yoon Hyuck Kim, Jae-Seung Lee*
Division of Advanced Materials Engineering, Korea University, Korea
Poly(lactic-co-glycolic acid) (PLGA) is one of the most famous biocompatible and biodegradable polymers, and has been considerably studied in particulate forms in drug delivery systems. In order to improve the functions of PLGA particles, many additives have been used in the synthesis of PLGA particles. Because the rapid drug release using PLGA particles is often essentially required for acute symptoms, the innate slow degradation rate of PLGA causes insufficient timely response to patients. In this study, we synthesized the PLGA particles with hierarchically interconnected nanopores using polyethylenimine (PEI) to enhance the drug release rate by enlarging the surface area of PLGA particles. The synthetic scheme presented in this work is much easier than those reported previously, and results in high size monodispersity. Most importantly, the size and porosity of the nanopores were easily controlled by the amount of PEI during the synthesis. Finally, we used doxorubicin (DOX) and the A549 cell line as a drug and target cells of our drug delivery model system, and evaluated the efficiency of the porous PLGA particles as drug carriers for acute symptoms. During the same incubation time, the DOX-loaded PLGA particles with the hierarchically interconnected nanopores exhibited five times as high efficacy as molecular DOX, which was determined in a series of quantified cell viability experiments.