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제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Design, synthesis, and anti-inflammatory evaluation of hydrogen sulfide donor-peptide hybrids

2019년 8월 29일 15시 15분 57초
MEDI.P-281 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 17일 (목요일) 11:00~12:30
Medicinal Chemistry
저자 및
Jae Wook Lee, Chung-Min Park1,*
Convergence Research Center for Dementia DTC, Korea Institute of Science and Technology, Korea
1Chemical Advanced Materials, Gangneung-Wonju National University, Korea
In recent years, hydrogen sulfide (H2S) has been known as a critical signaling molecule that regulates many physiological and/or pathological processes. Emerging evidence of its therapeutic value is that this endogenous gaseous substance can modulate inflammatory processes. Indeed, H2S donors have been shown to reduce edema formation and to inhibit pro-inflammatory cytokine synthesis. With the multiple biological actions of H2S, there is a growing interest in developing various H2S-releasing compounds for precise delivery of the gas to target tissues. Recently, combining nonsteroidal anti-inflammatory drugs (NSAIDs) with H2S-delivery components have been shown to exhibit improved efficacy and reduced toxicity. In our group, hydrogen sulfide (H2S)-releasing dithiolethione (ADT) functionalized with biologically active peptides has been investigated for their integrated anti-inflammatory and antioxidant potential. Series of ADT-peptides were synthesized and their inhibitory effects on LPS-induced inflammation in RAW264.7 cells were evaluated. Herein, our results demonstrate that the combination of H2S donors with biological peptides have more potent effects. It would lead to promising anti-inflammatory agents for the treatment of peripheral and central inflammation.