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  • 09월 10일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Mimicry of the Cytoskeleton: Actin and Microtubule Polymerization in Giant Unilamellar Vesicle causing Shape Changing

2019년 8월 29일 16시 05분 58초
LIFE.O-5 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 10시 : 00분
Life Chemistry - Oral Presentations by Young Life Chemists
저자 및
Sungwoo Jeong, ChangHo Kim1, Kwanwoo Shin*
Department of Chemistry, Sogang University, Korea
1Institute of Biological Interfaces, Sogang University, Korea
Microtubule and actin cytoskeletons are physically contacted in a cell and dynamically coordinated to play vital roles in many cell functions, from migration, growth, and division. These structural dynamics of cytoskeletal proteins are of interest, the physical roles of cross-linking proteins between two filaments have been identified. Yet most studies were performed in a highly controlled interface or a bulk. Recently, we developed to simulate a cytoskeleton formation through ATP-dependent actin polymerization in a giant unilamellar vesicle (GUV) Optical stimulation-initiated ATP synthesis and induced ATP-dependent actin polymerization, leading to the growth of three-dimensional highly curled actin filament network. In this study, we further added the ingredients for microtubule formation into the actin polymerizable GUV system and controlled both of the polymerization via single divalent cation Mg2+. Also, by adapting the lipid phase separation techniques in the GUV system, the GUV could bare any physical forces generated during the polymerizations. We will discuss how the lipid phase-separated GUV showed structurally and shape change during the cytoskeleton proteins polymerization. At last, we will discuss how these shape changes and the cytoskeleton co-polymerizable GUV system could lead to artificial cellular movements in future research.