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  • 09월 10일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Development of a Highly Stable Donor-Acceptor Type Fluorophore Based on Naphthoxazepine Scaffold and Its Applications in Bio-imaging

2019년 8월 29일 16시 36분 07초
MAT.P-386 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 17일 (목요일) 11:00~12:30
Material Chemistry
저자 및
Heejo Moon, Youngseo Kim1, Sungnam Park1,*, Byeong Moon Kim2,*, Dokyoung Kim3,*
Department of Chemistry, Seoul National University, Korea
1Department of Chemistry, Korea University, Korea
2Division of Chemistry, Seoul National University, Korea
3College of Medicine, Kyung Hee University, Korea

Oxazepines are unsaturated seven-membered heterocyles containing an oxygen and a nitrogen. It has been reported that some oxazepines show interesting biological activities such as antitumor, anti-inflammation, antimicrobiotic acitivites. Especially, medicinally important drugs including Amoxapine, Loxapine, and Nitroxazepine have distinctive structural features consisting of oxazepine backbone with hybridization of two benzene rings. In this work, we developed a new donor–acceptor type napthalene-based oxazepine fluoropore, OXN-1, which exhibits high chemcial stability in harsh conditions. Its exceptional structural stabilities and photophysical properties were thoroughly examined and further explained by quantum chemical calculations. Its bioimaging capabilities for cells with low cytotoxicity were verified. In addition, its deep tissue imaging capability with two-photon microscopy (TPM) was evaluated. These findings may present OXN-1 as a new promising fluorescent probe in biomedicinal application.