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  • 09월 10일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

대한화학회 제124회 학술발표회 및 총회 A highly sensitive and stable Radio-isotope embedded AuNPs for PET imaging agent

등록일
2019년 8월 29일 17시 11분 47초
접수번호
1909
발표코드
MAT.P-392 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 17일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Material Chemistry
저자 및
공동저자
Wonseok Yang, Dongkwon Lim*
KU-KIST Graduate School, Korea University, Korea
Novel imaging agents with high sensitivity and stability are needed to accurately detect unstable plaques for successful cardiovascular disease. Herein, radio-isotope embedded gold nanoparticles (RIe-AuNPs) can play an important role in the diagnosis of cancer of inflammatory disease as a positron emission tomography (PET) imaging probe1. The RIe-AuNPs were synthesized in straightforward DNA or peptide-based radiolabeling chemistry and additional Au shell formation strategies, leading to high radio-sensitivity and outstanding in vivo stability2,3. Such RIe-AuNPs could demonstrate stable and accurate targeting ability in abnormal blood vessels with densely localized macrophages by modifying specific ligand effective for atherosclerosis. Given such imaging capability to accurately monitor lesion, RIe-AuNPs with specific ligand hold great potential as a highly sensitive and stable PET imaging agent for cardiovascular disease.

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