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학술발표회초록보기

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  • 09월 10일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 NIR Emissive C2V Symmetric Pyridinium Salt: Selective Discrimination Capabilities G-Quadruplexes over Canonical/Non-Canonical Nucleic Acids and Their In-Cellulo Demonstrations

등록일
2019년 8월 30일 15시 25분 39초
접수번호
1931
발표코드
LIFE.O-6 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 10시 : 15분
발표형식
구두발표
발표분야
Life Chemistry - Oral Presentations by Young Life Chemists
저자 및
공동저자
Anup Pandith
Department of Chemistry, Chonbuk National University, Korea

G-quadruplexes (G4s) are non-canonical nucleic acids which can regulate various metabolic process in physiological systems. Due to its inevitable applications in genetics and therapeutics its recognitions in genome attracts great interest both chemical-biologists and genetic engineers. Considering the significance of G4s, current work we report small and highly efficient novel NIR emissive C2V symmetric pyridinium salt (1) was utilized to identify G4s in invitro as well as in in-cellulo. Rationally designed probe 1, showed selective switch-on response in NIR region (emission centred at 620 nm) without inducing any background signals from dsDNA, ssDNA, RNA and other non-canonical nucleic acids viz., triplex, three-way junction etc. Additionally, strategic design and sensing capabilities were supported through model compounds 2, 3 and 4 using UV-Vis, fluorescence, gel electrophoresis, and dynamic light scattering (DLS) studies.


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