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학술발표회초록보기

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  • 09월 10일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Rh(III)-Catalyzed Synthesis of N-heterocyclic compounds and its application to bioimaging agent

등록일
2019년 8월 30일 17시 07분 02초
접수번호
1935
발표코드
MEDI.O-6 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 10시 : 15분
발표형식
구두발표
발표분야
Medicinal Chemistry - Oral Presentation of Young Discovery Chemists
저자 및
공동저자
Sangbong Lee, Ye Ri Han, Jungwook Chin, Su-Jeong Lee, Minseon Jeong, Sung Jin Cho*, Dong-Su Kim*
New Drug Development Center, Daegu Gyeongbuk Medical Innovation Foundation, Korea
Synthesis of N-heterocylic compounds using Rh(III) catalysis received great attentions in various fields of studies such as pharmaceutical and materials area. Recently, we developed synthetic methods for the synthesis of N-heterocyclic salt compounds using Rh(III)/Cu(II) complex. Interestingly, we found that their fluorescent spectra showed over the full color region. Based on these previous studies, we attempted for application of fluorescent materials to diagnostic bioimaging in vivo model. For successful application of fluorescent materials as imaging agent, several in vitro and in vivo experiments were performed. As a result, we found that benzoquinolizinium salt may serve as an in vivo imaging agent for detection of inflamed lesions. This result can be applied to the diagnosis of disease.

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