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학술발표회초록보기

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  • 09월 10일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Visible-Light Induced C-O Bond Formation for Construction of Cyclic Ethers and Lactones

등록일
2019년 9월 9일 08시 36분 18초
접수번호
1963
발표코드
ORGN.P-450 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 18일 (금요일) 11:00~12:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Honggu Im, Sungwoo Hong*
Department of Chemistry, Korea Advanced Institute of Science and Technology, Korea

Intramolecular benzylic C−O bond formation was developed using 2,4,6-triphenylpyrylium tetrafluoroborate (TPT), which allows construction of cyclic ethers and lactones. The reaction is supposed to proceed through the single-electron oxidation of the phenyl group, followed by the formation of a benzylic radical, thus preventing a competing 1,5-hydrogen abstraction pathway. Detailed mechanistic studies suggest that molecular oxygen is used to trap the radical intermediate to form benzyl alcohol, which undergoes cyclization. This new approach serves as a powerful platform by providing efficient access to valuable 5- and 6-membered cyclic ethers and lactones with a unified protocol. Reference Im, H.; Kang, D.; Choi S.; Shin S.; Hong, S.* Org. Lett. 2018, 20, 7437.


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