The regioselective Pd-catalyzed hydroalkoxylation reaction between ene-alkoxyallenes and 2,3,4-triol hexopyranosides is reported.1 The strategy can provide complex oligosaccharides in high stereoselectivity with no need of protection of hydroxy groups. In this presentation, the optimization of reaction conditions and its potential application for the synthesis of various complex oligosaccharides will be introduced.
1 a) Lim, W.; Kim, J.; Rhee, Y. H., J. Am. Chem. Soc. 2014, 136 (39), 13618-13621; b) Lee, J.; Kang, S.; Kim, J.; Moon, D.; Rhee, Y. H., Angew. Chem. Int. Ed. 2019, 58 (2), 628-631.