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제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 A Synthetic Study towards Total Synthesis of 7-Oxostaurosporine by using Palladium-Catalyzed Asymmetric Addition Reaction of Bis-indole to Alkoxyallenes

등록일
2019년 9월 9일 14시 33분 41초
접수번호
1996
발표코드
ORGN.P-456 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 18일 (금요일) 11:00~12:30
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Seok Hyeon Jang, Young Ho Rhee*
Department of Chemistry, Pohang University of Science and Technology, Korea

Staurosporine has interesting biological properties including antifungal and hypotensive activities. Its cytotoxic activity was based on the inhibition of protein kinase C. Herein, a new concise synthetic method towards 7-oxostaurosporine will be presented. Key features of this reaction include i) Palladium-catalyzed asymmetric addition of bis-indole to alkoxyallenes1, ii) Ruthenium-catalyzed ring closing metathesis(RCM) and iii) Ruthenium-catalyzed olefin migration of cyclic allylic acetal2. By using these reactions, Key intermediate of 7-oxostaurosporine could be obtained with high synthetic efficiency.

Reference

1) Jang, S.H. ; Kim, H.W. ; Jeong, W. ; Moon, D. ; Rhee, Y.H., Org. Lett., 2018, 4, 1248. 2) Seo, K. ; Kim, Y.J. ; Rhee, Y.H., Org. Lett., 2018, 4, 979.


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