The Cervimycins containing 2,3,6-trideoxy-tetrasaccharide have bioactivity against multi-drug-resistant bacteria. Because of these utilities, Cervimycins have drawn considerable attention from synthetic community. We present here a convergent synthetic study toward tetrasaccharide moiety of Cerivimycin A1. Key feature of this strategy is represented by the Pd-catalyzed asymmetric hydroalkoxylation of alkoxyallene which allows for the efficient coupling of the aglycon and the tetrasaccharide moiety.
1. (a) Lee, J.; Kang, S.; Kim, J.; Moon, D.; Rhee, Y. H., Angew. Chem. Int. Ed. 2019, 58