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  • 09월 10일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Construction of Chemical Library and Preparation of Drug-like Thiazole Derivatives using Solid-Phase Synthesis

2019년 9월 9일 15시 20분 36초
MEDI.P-286 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 17일 (목요일) 11:00~12:30
Medicinal Chemistry
저자 및
Yeeun Noh, SuJeong Kim, Hyeok Jin Lee, Jimin Moon1, YoungBeom Kim, Taeho Lee2,*
Kyungpook National University, Korea
1college of pharmacy, Kyungpook National University, Korea
2Department of Pharmacy, Kyungpook National University, Korea
Combination chemistry plays an important role in drug development because it is effective in building libraries of large amounts of compounds. In this study, we used a solid-phase synthesis method of combinatorial chemistry to build a library of ring-type thiazole derivatives among heterocyclic compounds that are biologically active and to find drug-like compounds. Thiazoles are five-membered ring heterocycles and their derivatives are considered a pharmacologically significant active scaffold that has almost all types of pharmacological activities. Their presence in peptides, their ability to bind to proteins, DNA, and RNA, as well as the exceptional range of antibacterial, antifungal, anti-inflammatory, anthelmintic, sedative, hypnotic, and antiretroviral properties of thiazole-containing compounds have directed numerous synthetic studies and new applications. Additionally, thiazoles are important features of various peptides and pseudopeptides that function as potent antineoplastic agents, or have demonstrated significant cytotoxicity or antibiotic properties. Owing to these interesting activities, we will build a large library through solid phase synthesis, which can produce a thiazole structure similar to other drugs. They are expected to have important biological activity and consequentially the production of large numbers of derivative libraries are likely to increase the possibility of drug development and supposed a significant role in the pharmaceutical industry.