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  • 09월 10일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Selenium-based ROS Biological Probes: Mycophenolic acid Core Intermediates as a New Chemosensing Fluorophore Class

2019년 9월 9일 16시 54분 14초
INOR.P-128 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 17일 (목요일) 11:00~12:30
Inorganic Chemistry
저자 및
David George Churchill
Department of Chemistry, Korea Advanced Institute of Science and Technology, Korea

Herein, we have designed, synthesized, and characterized novel compounds. We have been interested in targeting organoselenium-based molecules (Probe-1 and Probe-OCl) based on a synthetic intermediate of mycophenolic acid (MPA) for the aqueous detection of OCl-. Hypochlorous (OCl-) ion is the most well-known bacterial oxidant; it is produced by neutrophils. Excess amounts of OCl- are known to cause various disorders in living systems. Both molecular probes show immediate “turn on” fluorescence upon the addition of OCl-; they display an increase in the fluorescence quantum yield (3.7-fold for Probe-1 and 11.6-fold for Probe-OCl) and are completely soluble in aqueous media without the help of cosolvent (see figure below). However, a decrease in “turn-on” intensity with the oxidized version (-Se(O)-) of Probe-1 in cell assays due to the anhydride/phthalate functional group suggests probe degradation is occurring based on the hydrolytic action (probe degradation half-life = ~1500 seconds at 15 μM of Probe-1 and 150 μM OCl). Thus, the change of “anhydride” to “methylamide” affords Probe-OCl more stability without sacrificing its water solubility properties. We are derivatizing further to expand the practicality of this fluorophore class.