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  • 09월 10일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Selenium-based ROS Biological Probes: Mycophenolic acid Core Intermediates as a New Chemosensing Fluorophore Class

등록일
2019년 9월 9일 16시 54분 14초
접수번호
2026
발표코드
INOR.P-128 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 17일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Inorganic Chemistry
저자 및
공동저자
David George Churchill
Department of Chemistry, Korea Advanced Institute of Science and Technology, Korea

Herein, we have designed, synthesized, and characterized novel compounds. We have been interested in targeting organoselenium-based molecules (Probe-1 and Probe-OCl) based on a synthetic intermediate of mycophenolic acid (MPA) for the aqueous detection of OCl-. Hypochlorous (OCl-) ion is the most well-known bacterial oxidant; it is produced by neutrophils. Excess amounts of OCl- are known to cause various disorders in living systems. Both molecular probes show immediate “turn on” fluorescence upon the addition of OCl-; they display an increase in the fluorescence quantum yield (3.7-fold for Probe-1 and 11.6-fold for Probe-OCl) and are completely soluble in aqueous media without the help of cosolvent (see figure below). However, a decrease in “turn-on” intensity with the oxidized version (-Se(O)-) of Probe-1 in cell assays due to the anhydride/phthalate functional group suggests probe degradation is occurring based on the hydrolytic action (probe degradation half-life = ~1500 seconds at 15 μM of Probe-1 and 150 μM OCl). Thus, the change of “anhydride” to “methylamide” affords Probe-OCl more stability without sacrificing its water solubility properties. We are derivatizing further to expand the practicality of this fluorophore class.


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