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  • 09월 10일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Ultrasensitive electrochemical aptasensor for Hg2+ using DNA coated reduced graphene oxide electrode

등록일
2019년 9월 9일 17시 16분 20초
접수번호
2032
발표코드
ELEC.P-449 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 17일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
Electrochemistry
저자 및
공동저자
SuHwan Yu, Tae Hyun Kim1,*
Chemistry, Soonchunhyang University, Korea
1Department of Chemistry, Soonchunhyang University, Korea
A highly sensitive electrochemical sensor was developed for the detection of Hg2+ ions in aqueous solution using a thymine (T)-rich aptamer and reduced graphene oxide (RGO) modified electrode. The method used methylene blue (MB) tagged aptamer which characteristic of electrochemical signal indicator. ERGO was synthesized and deposited on a glassy carbon electrode to enhance the electrode’s conductivity, surface and conjugate the MB tagged aptamer by π-π interaction. In the presence of Hg2+, the MB tagged aptamer on the RGO modified electrode builds a hairpin structure which results in its subsequent detachment from the RGO surface. This conformational change causes significant decrease in voltammetric signals. We demonstrated that this sensing strategy showed high sensitivity and selectivity for Hg2+ detection. The fabricated aptasensor showed a linear detection range of 1 fM to 100 nM and detection limits of 0.16 fM for Hg2+. This aptasensor could be regenerated using cysteine.

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