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제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Near-Infrared Molecularly Imprinted Polymers-Based Sensor for Ultrasensitive Detection of Pharmaceutical Residues in wastewater

2019년 8월 19일 17시 26분 14초
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목 09시 : 06분
Analytical Chemistry - Oral Presentation of Young Analytical Chemists I
저자 및
Mohamed Ragab Elsayed Ali, Salah Mahmoud Tawfik Ahmed, Yong-Ill Lee*
Department of Chemistry, Changwon National University, Korea
One of the alternative techniques for determining pharmaceuticals and their metabolites in the aquatic environment is the use of molecularly imprinted polymers (MIPs) as recognition systems. MIPs are tailor-made artificial receptor sites in a polymer, which possess good affinity and selectivity. This work presents the design of new optical sensor-based MIP for the detection of Carbamazepine (CBZ) as one of the most frequently detected pharmaceutical residues in wastewater. MIP was prepared via in situ photopolymerization process using upconversion nanoparticles (UCNPs), CBZ, N-allyl-3,4,5-trihydroxybenzamide, (E)-N-acryloyl-3-(3,4-dihydroxyphenyl)acrylamide and 1-(carboxymethyl)-4-vinylpyridin-1-ium bromide, ethylene-glycol dimethacrylate, eosin Y/ triethylamine (TEA) as fluorescent materials, template, functional monomers, cross-linking agent, and an initiating system, respectively. Our method utilizes the internal visible light emitted from UCNPs upon photoexcitation with near-infrared radiation, to locally photopolymerize a thin polymer shell of the MIP around the UCNPs. The TEM images of this hybrid showed an ultrathin shell of 2.5 nm thickness. Under optimum conditions, the results of the fluorescence quenching analysis showed excellent sensitivity (LOD, 28.5 pM) with good linear ranges of 0.5 nM to 500 μM for CBZ and a correlation coefficient of 0.992. Moreover, the practical application of the developed sensor for CBZ detection in tap and river water samples has been successfully described with satisfactory recoveries of 98.24-104.23% and RSD less than 5%. This work offers a novel facile strategy to develop a fluorescent sensor with selective, rapid and accurate detection of CBZ in the wastewater. Keywords: molecular imprinting polymer, in situ photopolymerization, UCNPs, CBZ.