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09월 10일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능
대한화학회 제124회 학술발표회 및 총회
Identification multidisciplinary function and analysis active chemical compound structure of natural biological resources that were collected from Southern-east asian countries
2019년 8월 21일 15시 26분 08초
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금 09시 : 18분
Analytical Chemistry -
Oral Presentation of Young Analytical Chemists II
, TaeYeong Park
, Dong-Ku Kang
Chemistry, Incheon National University, Korea
Department of Cosmetic Science & Management, Incheon National University, Korea
Department of Chemistry, Incheon National University, Korea
This study aims to derive multi-function material from biological natural resources and also to identify its chemical structure. Candidate materials were collected from southern-east asian countries and one-hundred samples were provided for the screening of functional materials. First, dried samples were homogenized and extracted with 70% ethanol and then antimicrobial activity was identified using conventional ‘paper disc assay’ against infectious pathogens including
. Antioxidant activity was also validated by conventional ABTS(2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid)) assay and effect of cellular ROS concentration was characterized using 'DCF-DA'-based cell staining approach. After 1
screening of antimicrobial activity with paper disc assay, IC
values of derived candidates were characterized for the quantification of antimicrobial activity using alamarBlue-based cell viability assay. Finally, one of the candidates was characterized which has both antimicrobial and antioxidant activities. The IC
values of X were identified as 0.294, 2.340, 2.175 and 3.699 mg/ml against
respectively. Moreover, the IC
value of antioxidant for X was calculated as 4.157 μg/ml. Then, active chemical compound was purified by fractionation using prep-HPLC. The activities of antimicrobial and antioxidant were confirmed with paper disc-based susceptibility test and ABTS assay respectively. Finally, their cellular action mechanism and biocompatibility were also identified.
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