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09월 10일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능
대한화학회 제124회 학술발표회 및 총회
Investigation of serum lipid signatures of pig in post-hepatectomy liver failure from expanded hepatectomy using nanoflow UHPLC-ESI-MS/MS
2019년 8월 22일 12시 53분 16초
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금 09시 : 27분
Analytical Chemistry -
Oral Presentation of Young Analytical Chemists II
, JongCheol Lee
, Myeong Hee Moon
Department of Chemistry, Yonsei University, Korea
The liver is an important organ that is involved in numerous biochemical reactions andlipid metabolism. Because the liver is an excellent regenerative organ, liver resection is usually performed when liver cancers were developed. However, hepatectomy may cause a variety of complications. The biggest contributor to mortality from liver resection is a post-hepatectomy liver failure (PHLF) which is the inability of the liver to perform its normal synthetic and metabolic functions after liver resection. Therefore, an early and quick diagnose of PHLF is still an important issue. In this experiment, pigs were divided into three groups of six laparotomized pigs (sham), seven 70% partial hepatectomized pigs (the 70% PH group), and seven 90% partial hepatectomized pigs (the 90% PH group) to obtain sera at each time points: pre-operation (PO), 14 hours (14h), 30 hours (30h), and 48 hours after the operation. The lipids extracted from sera were analyzed using nanoflow ultrahigh-pressure liquid chromatography electrospray ionization tandem mass spectrometry (nUHPLC-ESI-MS/MS) and 284 lipid species were structurally confirmed by collision-induced dissociation (CID) experiments. Among them, 184 lipid species were quantified by selective reaction monitoring (SRM) mode. From the statistical analysis, eleven lipids showed significant differences (> 2-fold, p < 0.01) between the 70% and the 90% PH groups at 30 hours after the operation. Among the lipids, TG was decreased considerably at 90% PH. PC plasmalogen was increased at 90% PH and showed significant correlation (Pearson’s r > 0.7, p < 0.05) with total bilirubin (TBIL) and prothrombin time (PT) which indicate liver function.
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