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제124회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Antioxidative Activity of Oligosaccharides on UV-induced Photoaging in human skin cells

2019년 8월 27일 14시 36분 35초
ANAL2.O-17 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 09시 : 48분
Analytical Chemistry - Oral Presentation of Young Analytical Chemists II
저자 및
Ara Lee, Dong-Ku Kang*
Department of Chemistry, Incheon National University, Korea
Ultraviolet (UV) is one of the major reasons for the skin aging and its intracellular action mechanisms are well-defined as 1) mitochondrial damage due to UV-induced reactive oxygen species (ROS) and 2) collagen collapse in the subcutaneous layer due to increased expression of matrix metalloproteinase (MMP). Thus, antioxidants are commonly used as an anti-aging agents to inhibit free radicals produced by UV such as ROS. Oligosaccharides are kind of carbohydrates that have various biological activities such as improving intestinal environment and immune stimulation. Recently, antioxidant activity of oligosaccharides has been also identified from few kinds of oligosaccharides. In this study, seaweed-derived oligosaccharides were identified on anti-photoaging that was induced by ultraviolet B (UVB) irradiation in human keratinocytes (HaCaT cells). Reductive activity was validated using conventional ABTS assay with nine individual oligosaccharides and result indicated that neoagarooctaose (NA8) and neoagarodecaose (NA10) have reducing power. In HaCat cell-based antioxidant experiments, NA10 also inhibits ROS formation and ERK 1/2 phosphorylation. Finally, MMP-1 production was also interfered by NA10 treatment in HaCat cells. There experimental results suggested that NA10 has a potential for the skin anti-photoaging.