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  • 05월 20일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제125회 대한화학회 학술발표회 및 총회 Synthesis and characterization of core-shell Fe3O4@SiO2 nanobeads as adsorbents for magnetic separation of nucleic acids

2020년 1월 20일 16시 09분 29초
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Physical Chemistry
저자 및
Huan Yue, Gang Ho Lee*
Department of Chemistry, Kyungpook National University, Korea
There are many researches on magnetic nanobeads have attracted a lot of attentions recently, because they can be applied to a variety of biomedical areas. Using their specific binding properties and strong superparamagnetic properties of the surface functional groups, they can be applied to the separation of biological molecules such as DNA, RNA, proteins, and nucleic acids from blood samples. In this research, the separation of nucleic acids from blood samples of patients was studied. To this end, core-shell structured silica-coated iron oxide (Fe3O4@SiO2) nanobeads were synthesized Stöber method, and characterized by Fourier transformed-infrared spectroscopy, X-ray diffraction, high-resolution transmission electron microscopy, and vibrating sample magnetometry. The synthesized Fe3O4@SiO2 nanobeads exhibit a size distribution of 30-40 nm and a high saturation magnetization. In addition, in vitro cytotoxicity showed a good biocompatibility. They exhibited excellent adsorption and magnetic separation performance for the purification of nucleic acids from blood samples of patients. Therefore, the core-shell Fe3O4@SiO2 nanobeads can provide a fast, easy, and efficient purification method of nucleic acids from blood samples of patients.