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  • 05월 20일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제125회 대한화학회 학술발표회 및 총회 In vivo T1 MR imaging application of water soluble Poly(methyl vinyl ether-alt-maleic acid)-coated Ultrasmall Gd2O3 Nanoparticles

등록일
2020년 1월 20일 17시 43분 40초
접수번호
0036
발표코드
PHYS.P-209 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
온라인 PDF 제출
발표형식
포스터
발표분야
Physical Chemistry
저자 및
공동저자
Mohammad Yaseen Ahmad, Gang Ho Lee1,*
Kyungpook National University, India
1Department of Chemistry, Kyungpook National University, Korea
(PMVEMA)-coated gadolinium oxide nanoparticles (Gd2O3 NPs) with ultrasmall particle size distributions (davg = 1.9 nm) were synthesized using one-pot polyol synthesis. The PMVEMA-coated Gd2O3 NPs exhibited excellent colloidal stability in water and good biocompatibility in cellular toxicity tests. The r1 relaxivity value of 36.3 s-1mM-1 which is approximately ten times higher than those of commercial molecular contrast agents. This high r1 value was attributed to large hydration diameters of the PMVEMA-coated Gd2O3 NPs (aavg = 18.6 nm). The effectiveness of the PMVEMA-coated Gd2O3 NPs was demonstrated by taking in vivo T1 MR images in mice. Strong positive contrast enhancements were observed in T1 MR images after intravenous administration of the solution sample into mice tails, demonstrating that the PMVEMA-coated Gd2O3 NPs act as a T1 MRI contrast agent.

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