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  • 05월 20일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제125회 대한화학회 학술발표회 및 총회 Development of a single fluorescent probe capable of detecting dual imaging viscosity and nitric oxide

등록일
2020년 1월 28일 17시 03분 18초
접수번호
0081
발표코드
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발표시간
온라인 PDF 제출
발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Su Jung Kim, Sun Young Park1, Min Hee Lee1,*
Department of chemistry, Sookmyung Women's University, Korea
1Department of Chemistry, Sookmyung Women's University, Korea
Intracellular viscosity is an important physical parameter and Nitric oxide (NO) is an essential gas signaling molecule involved in many physiological processes. Irregular viscosity in the cell and the production of NO cause various diseases. However, fluorescent probes capable of detecting both viscosity and NO have not been studied. So, we designed and synthesized probe <1> for dual imaging of viscosity and exogenous and endogenous NO in living cells. Probe <1> has no fluorescence due to N-N single bond free rotation. When the viscosity increases, free rotation is prohibited, resulting in significant blue fluorescence. In addition, probe <1> and NO can react to form compound 2, which emits a pronounced green fluorescence. Moreover, probe <1> had low toxicity in living cells, fluorescence was observed according to the viscosity change in the blue channel, and changes in exogenous and endogenous NO concentrations were observed by imaging in the green channel. Most notably, we were able to study the relationship between viscosity and NO in living cells with probe <1> for the first time, which can help with many pathological basic studies.

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