abs

학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 05월 20일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제125회 대한화학회 학술발표회 및 총회 Pyrazolo[1,5-a][1,3,5]triazin-4-amine derivatives : Synthesis of a Novel Class of SIRT6 Activators

등록일
2020년 2월 3일 10시 41분 33초
접수번호
0160
발표코드
MEDI.P-692 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
온라인 PDF 제출
발표형식
포스터
발표분야
Medicinal Chemistry
저자 및
공동저자
Hyounwoo Lim
new medical development, Chungbuk Natioanl University, Korea
To develop a novel SIRT 6 Activator, We synthesized 8-(4-Phenoxyphenyl)-N-(2-(pyrrolidin-1-yl)ethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine (7), which was prepared in several steps from (1). 5-Amino-1H-pyrazole-1-carboxamide (2) was obtained by adding isoxazole (1) to semicarbazide hydrochloride. Pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one (3) was formed by cyclization of 5-Amino-1H-pyrazole-1-carboxamide (2), which was reacted with triethyl orthoformate. N-Methyl-N-phenylpyrazolo[1,5-a][1,3,5]triazin-4-amine (4) was obtained by chlorination in N-methyl aniline and 8-iodo-N-methyl-N-phenylpyrazolo[1,5-a][1,3,5]triazin-4-amine (5) was obtained by iodination at the 8-position. Various functional groups were reacted in the presence of Suzuki reaction to give N-methyl-N-phenylpyrazolo[1,5-a][1,3,5]triazin-4-amine (6), which were converted into the several compounds of amino function in the 4-position (7).

상단으로