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  • 05월 20일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제125회 대한화학회 학술발표회 및 총회 Supramolecular latch: Synthetic high-affinity molecular anchoring tool for chemical biology and biomedicine

2020년 2월 3일 23시 49분 54초
LIFE2-2 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
화 13시 : 30분
Life Chemistry - Current issues in Nanobio Science
저자 및
Kyeng Min Park
Center for Self-assembly and Complexity, Institute for Basic Science, Korea
Streptavidin (Sv)-biotin (BT) binding system has been exploited as a useful molecular anchoring tool for protein imaging, purification, and analysis mostly due to its high binding affinity. However, the Sv-BT pair has unavoidable demerits since it is originated from proteins. Recently, we developed a high-affinity synthetic binding pair, namely “supramolecular latch” based on unique host-guest interactions between cucurbit[7]uril (CB[7]) and its guests having almost comparable (or even higher) binding affinity to Sv-BT with unique features including bio-orthogonality and binding controllability. Here, I will talk about our recent results with this supramolecular latch tool for chemical biology. In addition, our extended efforts to utilize it for a practical application such as cost-effective purification of protein therapeutics in high purity will be discussed. References [1] Ghosh; S. K.; Dhamija, A.; Ko, Y. H.; An, J.; Hur, M. Y.; Boraste, D. R.; Seo, J.; Lee, E.*; Park, K. M.*; Kim, K.*, J. Am. Chem. Soc. 2019, 141, 17503-17506. [2] Park, K. M.*; Hur, M. Y.; Ghosh, K. S.; Boraste, D. R.; Kim, S.; Kim, K.* Chem. Commun. 2019, 55, 10654-10664. [3] Park, K. M.*; Baek, K.; Ko, Y. H.; Shrinidhi, A.; Murray; Jang, W. H.; Kim, K. H.; Lee, J.-S., Yoo, J.; Kim, S.; Kim, K.* Angew. Chem. Int. Ed. 2018, 57, 3132-3136. [4] Li, M.; Lee, A.; Kim, K. L.; Murray, J.; Shrnidhi, A.; Sung, G.; Park, K. M.*; Kim, K.* Angew. Chem. Int. Ed. 2018, 57, 2120-2125. [5] Kim, K. L.; Sung, G..; Sim, J.; Murray, J.; Li, M.; Lee, A.; Shrinidhi, A.; Park, K. M.*; Kim, K.* Nat. Commun. 2018, 9, 1712.