abs

학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 09월 06일 15시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제112회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Iron(II)-Catalyzed Tandem Cyclization and Cross-coupling Reaction of Iodoalkanes and Aryl Grignard Reagents

등록일
2013년 8월 29일 12시 56분 23초
접수번호
0836
발표코드
ORGN.O-3 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 10시 : 30분
발표형식
구두발표
발표분야
유기화학 - Oral Presentation for Young Organic Chemists
저자 및
공동저자
김재곤, 강은주1,*
경희대학교 화학과, Korea
1경희대학교 응용화학과, Korea

Iron-catalyzed cross-coupling reactions have been intensely investigated in recent years, while palladium- and nickel-catalyzed cross-coupling reactions of aryl and vinyl halides have evolved over decades into mature tools for advanced organic synthesis. The most valuable characteristic of iron catalysis in cross-coupling reactions may be the unprecedented reactivity toward alkyl halides. Alkyl halides are considered challenging substrates because they resist oxidative addition, and the resulting metal reagents have proclivity for β-hydride elimination. Despite a number of reports on iron-catalyzed cross-coupling reactions of alkyl halides, the tandem reaction protocol was not investigated in detail. We have demonstrated that tandem cyclization and alkyl-aryl cross-coupling of primary and secondary alkyl iodides with aryl Grignard reagents can be realized by using an FeCl2 catalyst to afford arylmethyl-substituted heterocycles; a range of arylmethyl substituted pyrrolidines and tetrahydrofurans. Several experimental results, such as stereochemical outcome of secondary iodide substrate and intermediate identification with TEMPO, support the radical process of this catalytic system. In future studies, we aim to discover efficient tandem reactions expanded by this versatile iron catalysis to fully explore its preparative scope.


상단으로