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  • 05월 20일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제125회 대한화학회 학술발표회 및 총회 Comparative Investigation on the Structural and Thermodynamic Characteristics between Wild-Type and Mutation of SOD1

등록일
2020년 2월 5일 13시 58분 21초
접수번호
0393
발표코드
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발표시간
온라인 PDF 제출
발표형식
포스터
발표분야
Physical Chemistry
저자 및
공동저자
Haeri Im, Song-Ho Chong, Sihyun Ham*
Department of Chemistry, Sookmyung Women's University, Korea
Amyotrophic lateral sclerosis (ALS) is a selective dying disease of the spinal motor nerves. Although it is a progressive incurable disease, there is no proper treatment currently available. Excessive SOD1 and its mutants undergo protein aggregations in neurons, which are supposed to spread to adjacent cells, leading to the death of nerve cells. Therefore, the mutation of the SOD1 induces genetic ALS, and it is presumed that it plays a role in the sporadic type of non-genetic ALS disease. In this study, we investigate the effect of individual mutations on the structural and thermodynamic properties of the SOD1. We perform molecular dynamics simulations to probe structural changes induced by the mutations, and then carry out solvation free energy calculations to analyze thermodynamic features. Our study will contribute to an understanding of the SOD1 aggregation associated with ALS disease, and also provide the structural basis for developing drugs that inhibit the aggregation.

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