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  • 05월 20일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제125회 대한화학회 학술발표회 및 총회 Synthesis of Type III Post-Iboga Alkaloids

등록일
2020년 2월 5일 14시 45분 18초
접수번호
0408
발표코드
ORGN.P-515 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
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발표형식
포스터
발표분야
Organic Chemistry
저자 및
공동저자
Sikwang Seong, Sunkyu Han*
Department of Chemistry, Korea Advanced Institute of Science and Technology, Korea

Iboga alkaloids are a large family in natural products that possess both indole and isoquinuclidine moieties. Besides the structural features, their potential biological activities including anti-addiction, anti-cancer, and anti-bacterial have attracted enormous attentions and led to development of innovative synthetic routes to this family of natural products.
One of nature’s evolution strategy is maximizing the secondary metabolites from a common precursor. Inspired by this biosynthetic strategy, our group showed that some alkaloids (which we coined the term “post-iboga” alkaloids) were presumably biosynthetically derived from iboga alkaloids.1 In our previous studies, we were able to access type II post-iboga alkaloids voatinggine, tabertinggine as well as type III post-iboga alkaloid dippinine B.2 Herein, we present the broadened scope of synthetically accessible type III post-iboga alkaloids. We depict the biogenetically inspired transformation of catharanthine to type III post iboga alkaloids such as dippinine C and tronocarpine.

References
1. Lim, H.; Seong, S.; Han, S. Synthesis 2019, 51, 2737.
2. Seong, S.; Lim, H.; Han, S. Chem 2019, 5, 353.


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