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제125회 대한화학회 학술발표회 및 총회 Antibacterial activity of Ag-ZnO nanoparticles against clinical isolates of methicillin-resistant Staphylococcus aureus

2020년 2월 5일 14시 55분 27초
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Material Chemistry
저자 및
Atanu Naskar, Kwang-sun Kim1,*
Chemistry, Pusan National University, Korea
1화학과, Pusan National University, Korea
The increase in emergence and re-emergence of antimicrobial resistance (AMR) is widely acknowledged as a global health problem. However, the available solutions to tackle this problem are limited. In this scenario, nanomaterials can be potential alternatives to antibiotics or can be nano-weapon against AMR due to its favourable physiochemical properties. In the current study, one pot, low temperature solution technique was used to synthesize Ag-ZnO nanoparticles (AZO NPs) which showed targeted antibacterial activity against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) strains. X-ray diffraction (XRD) analysis was used to confirm the crystallinity and crystal phases of the nanoparticles. Transmission electron microscopic (TEM) analysis was used to evaluate the size and microstructure of the nanoparticles. X-ray photoelectron spectroscopic analysis was performed to confirm the oxidation state of the chemical elements present in the sample. Furthermore, the synthesized nanomaterials were evaluated for antibacterial activity against both Gram-negative (Escherichia coli and Acinetobacter baumannii, standard and AMR strains) and Gram-positive (Staphylococcus aureus, MRSA3, and MRSA6) bacteria by minimum inhibitory concentration, zone of inhibition and SEM microstructural analysis. The AZO NPs showed comparatively better antibacterial activity against Staphylococcus aureus and clinical isolates of MRSA strains than Gram-negative bacterial strains. Therefore, this synthesis strategy can be used to synthesize other nanobiomaterial for different biomedical applications especially antibacterial activity.