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  • 05월 20일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제125회 대한화학회 학술발표회 및 총회 Solid-phase Parallel Synthesis of 2,4,5-thiazole Derivatives Based on Peptidomimetics

등록일
2020년 2월 5일 15시 34분 53초
접수번호
0451
발표코드
MEDI.P-697 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
온라인 PDF 제출
발표형식
포스터
발표분야
Medicinal Chemistry
저자 및
공동저자
Min Jeong Cha, Sun Hwa Jung, Young Dae Gong*
Department of Chemistry, Dongguk University, Korea
Synthesis of peptidomimetics has known to be effective for better understanding of protein aggregation which causes neurodegenerative diseases such as Alzheimer’s disease. In this work, solid-phase synthesis of 2,4,5-thiazole derivatives based on peptidomimetics is described. The synthetic strategy starts from constructing 2,4,5-thiazole core skeleton resin by cyclization of resin-bound cyanocarbonimidodithioic acid with ethyl bromoacetate. The resulting core skeleton has amino group and carboxylic acid group which subsequently undergoes functionalization with various amino acids by amide coupling. The desired product has core skeleton of 2,4,5-thiazole with two sets of three successive amino acids. Trifluoroacetic acid (TFA) in dichloromethane (DCM) is used for cleaving the resin.

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