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제125회 대한화학회 학술발표회 및 총회 Inhibitory effect of lung cancer metastasis by new benzofuran compounds from Korean Mushroom, Suillus granulatus

2020년 2월 10일 16시 27분 00초
MEDI.P-709 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
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Medicinal Chemistry
저자 및
Seon-Jun Choi, Young Seok Kim1, Sang Il Jeon1, Jungyeob Ham*
Natural Products Research, Korea Institute of Science and Technology, Korea
1Department of Chemistry, Gangneung-Wonju National University, Korea
The methanol extract of Suillus granulatus was fractionated according to the polarity, and the ethyl acetate layer was selected and divided by reverse phase column and size exclusion chromatography. Suillusin and new substance Iso-Suillusin and 8-Hydroxy Suillusin were isolated from M2 fraction. Suillusin had an insufficient effect on biological activity in the previous reports, and it is an edible mushroom that has lower toxicity. As a result of measurement of a new activity on lung cancer metastasis, it had an inhibitory effect on the EMT phenomenon of lung cancer cell (A546 cell) by TGF beta. As a result of measurement of the activities of Iso-Suillusin and 8-Hydroxy Suillusin, too, their cytotoxicity was low, and the inhibitory effect on lung cancer metastasis was higher in Iso-Suillusin than suillusin and 8-Hydroxy Suillusin. Suillus granulatus had an inhibitory effect on lung cancer metastasis as an edible mushroom with low cytotoxicity. It is expected that it would have a less side effect and wider value of use since it has low cytotoxicity.