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제125회 대한화학회 학술발표회 및 총회 Synthesis and Biological Evaluation of Glycosylated Arylnaphthalene Lactone Derivatives as Anticancer Agents

등록일
2020년 2월 12일 14시 49분 25초
접수번호
1397
발표코드
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발표형식
포스터
발표분야
Medicinal Chemistry
저자 및
공동저자
Cheol Hee Yoon, Jiyool Kim1, Young-Tae Park1, Taejung Kim1, Chung-Min Park2, Jungyeob Ham1,*
chemistry, Gangneung-Wonju National University, Korea
1Natural Products Research, Korea Institute of Science and Technology, Korea
2Chemical Advanced Materials, Gangneung-Wonju National University, Korea
Justicidin A is a typical arylnaphthalene lactone lignan isolated from the plant Justica procumbens, which was found to have a wide spectrum of biological activities, such as cytotoxicity, antimicrobial and antiviral. Among these, the cytotoxicity is the most attractive, making arylnaphthalene lactone a good lead compound for anticancer drug design and development. On the other hand, the role of carbohydrates in biologically active natural products attracts much more attentions than before. With deep insights into the understanding of aglycone and glycoside activities, followed by the interesting stories of ouabain, rebeccamycin analogs with uncommon sugars and subtle sugar modification of digitoxin etc, the emphasis on the key requirement of sugars and in particular the common sugars is emerging as a new driving force in the development of new type distinct from the conventional ones. With the availability of the synthesized arylnaphthalene lactones in hand, and in particularly bearing in mind the critical contribution of sugar attachments to the outcome of molecular shape and biological diverse functions, we are encouraged to challenge the glycosylation manipulation to the R-OH, with the aim to probe insights into the SAR-based nature behind the glycosylated arylnaphthalene lactone derivatives via the synthesis and biological evaluation.

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