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제125회 대한화학회 학술발표회 및 총회 Synthesis and comparative anti-inflammatory activity of various sterols containing one double bond in the steroid backbone

등록일
2020년 2월 12일 19시 07분 15초
접수번호
1418
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발표형식
포스터
발표분야
Medicinal Chemistry
저자 및
공동저자
Jowon Hur, Hyejin Moon1, Hakwon Kim*, Jungwook Kim2, Dowon Yoon1, Taehoon Lee
Department of Applied Chemistry, Kyung Hee University, Korea
1Department of Chemistry, Kyung Hee University, Korea
2Department of Chemistry, Gwangju Institute of Science and Technology, Korea

Steroids are important components of cell membranes and are used as signaling molecules like hormones. Recently we have synthesized various sterols containing one double bond in the steroid backbone. According to the literatures, PtO2-catalyzed hydrogenation and subsequent allyllic isomerization of ergosterol and 7-dehydrocholesterol provides ∆8(14)-ergostenol and ∆8(14)-cholestenol. Also, their epimers were prepared by Mitsunobu reaction of the corresponding sterols. 5,6-Dihydroergosterol and ∆7-cholestenol were synthesized from the reduction of ergosterol or 7-dehydrocholesterol by Nickel(Ⅱ) Chloride. We compared the anti-inflammatory activity of eight monoene steroids, including commercial stigmasterol and cholesterol, which differ in the position of the double bond in the steroid backbone.


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