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  • 05월 20일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제125회 대한화학회 학술발표회 및 총회 Generation of Nucleic Acid Nanomachines That Perform Complex Functions

등록일
2020년 2월 14일 14시 19분 44초
접수번호
1709
발표코드
LIFE1-2 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
화 11시 : 20분
발표형식
심포지엄
발표분야
Life Chemistry - Nucleic Acid and Its Derivative Chemistry
저자 및
공동저자
Seung Soo Oh
Department of Materials Science and Engineering, Pohang University of Science and Technology, Korea
Over the last few decades, nucleic acids (e.g., DNAs and RNAs) have proven to be an exceptionally versatile material beyond genetic information storage. As a sequence controlled polymer, they fold into a unique structure and create a variety of functionalities including molecular recognition, catalysis, construction of complex patterns, and even nanomechanical motions. Importantly, these synthetic constructs can be programmed to perform a wide range of molecular functions in a controlled manner. They offer unique capabilities with regards to the creation of molecular machines that can perform complex functions in the right order at the right time – this is a powerful feature that cannot be easily realized in other macromolecules. To fully realize this potential, my work has focused on the development of novel methodologies to generate nucleic acid-based multi-functional biopolymers and their applications. Specifically, in this presentation, I will introduce an innovative in vitro selection strategy enabling the discovery of nucleic acid nanostructures that undergo binding-induced structure-switching. I will subsequently show that the generated synthetic allosteric regulators perform useful molecular functions for diagnostics, imaging and targeted therapy applications. Furthermore, I will demonstrate a unique catalytic RNAs (ribozymes) that recognize and polymerize the targeted short RNAs by processive ligation events.

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