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  • 05월 20일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

대한화학회 제125회 학술발표회 및 총회 Structure and functions of noncanonical DNAs

등록일
2020년 5월 25일 17시 25분 47초
접수번호
2548
발표코드
LIFE1-5 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
화 12시 : 20분
발표형식
분과기념
발표분야
Life Chemistry - Nucleic Acid and Its Derivative Chemistry
저자 및
공동저자
Kyeong Kyu Kim
Department of Medicine, Sungkyunkwan University, Korea
Most DNA in the genome is considered to be present as a B-form, but number of evidences support that DNA structures are highly polymorphic. Therefore, many sequence-specific noncanonical DNA (ncDNA) or non-B-DNA conformations transiently exist in the genome, often in response to changes in the cellular environment or when bound to proteins. A number of ncDNA structures including triplexes, hairpin, left-handed DNA, and G-quartet (tetraplexes) are involved in various cellular events including chromatin remodeling, replication, transcription and recombination, and thus its presence or mutation is relevant to the various disease including tumors. In addition, it is verified that many genetic diseases are closely related to ncDNA. Therefore, it is considered that regulation of ncDNA formation is crucial to understand its cellular function and to develop a novel strategy for curing the related diseases. In this presentation, current progress of our studies on the structure, function and modulation of ncDNA will be introduced.

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