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제126회 대한화학회 학술발표회 및 총회 Design and Synthesis of Novel Molecular Diversity for the Study of Protein-Protein Interactions

2020년 8월 25일 20시 03분 51초
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KCS - [IBS Symposium] Frontiers in Molecular Recognition and Self-assembly
저자 및
Seung Bum Park
Division of Chemistry, Seoul National University, Korea

Protein-protein interaction (PPI) plays a pivotal role in various biological systems and many complex diseases including cancer, neurodegenerative diseases, and metabolic diseases are often caused by aberrant PPIs. Given its significance in the biological systems, the identification of PPI modulators could be a starting point for drug discovery and chemical biology research. However, the high-throughput screening of conventional compound libraries hasn’t been successful, due to the different structural requirement of PPI modulators. Thus, there is a great demand in the construction of novel molecular diversity. Diversity-oriented synthesis (DOS) can provide a collection of diverse and complex drug-like small molecules, which is critical in the development of new chemical probes for biological research of undruggable targets. However, the design and synthesis of small-molecule libraries with improved biological relevance as well as maximized molecular diversity represents a key challenge. Herein, we employ functional group pairing strategy for the diversity-oriented synthesis of a chemical library containing privileged substructures, pyrimidodiazepine or pyrimidine moieties, as chemical navigators toward unexplored bioactive chemical space. This presentation highlights that privileged substructure-based DOS (pDOS) strategy can be a powerful research tool for the construction of drug-like compounds to address challenging biological targets.

References: [1] Kim, J.; Kim, H.; Park, S.B.* J. Am. Chem. Soc. 2014, 136(42), 14629–14638 [2] Choi, Y.†; Kim, H.†; Shin, Y.-H.; Park, S.B.* Chem. Comm. 2015, 51, 13040–13043 [3] Kim, C.†; Jung, J.†; Tung, T.T.; Park, S.B.* Chem. Sci. 2016 7, 2753–2761. [4] Kim, J.; Koo, J.; Jung, J.; Cho, W.; Kim, C.; Park, W.; Park, S.B.* Nat. Comm., 2016; 7: 13196. [5] Koo, J.; Kim, J.; Park, S. B.* Org. Lett., 2017, 19, 344–347. [6] Choi, Y.†; Kim, H.†; Park, S. B.* Chem. Sci., 2019, 10, 569–575* Fill in this blank within 1800 byte (In case of including Figures: within 1400 byte) * Attached Figures below (next page)