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  • 09월 23일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제126회 대한화학회 학술발표회 및 총회 A protocell as a molecular network system mimicking intracellular protein aggregation and its intra- and intercellular effects

2020년 8월 26일 10시 58분 50초
KCS4-3 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
수 14시 : 20분
KCS - [IBS Symposium] Frontiers in Molecular Recognition and Self-assembly
저자 및
Kyeng Min Park
Center for Self-assembly and Complexity, Institute for Basic Science, Korea
Undesirable aggregation of intrinsically disordered proteins including tau protein and α-synuclein causes progressive death of neuronal cells as neurodegenerative diseases including Alzheimer’s and Parkinson’s disease. The protein aggregation in cells and tissues is known to be promoted by oxidative stress under acidic conditions and affects the integrity of organellular and cellular membranes. However, the complex nature of physiological environments has hampered the deep investigation of the effect of the protein aggregation to the membranes causing propagative cell death. Recently, cell-like artificial microcompartments have been intensively investigated as protocells (or artificial cells) for better interrogating and understanding of cellular functions and behaviors of interest in a simplified form. A rational organization of chemical and biological components in a compartment allowed the construction of protocells mimicking important cellular functions and behaviors under a well-defined and controllable condition. Until recently, little effort has been devoted to construct a protocell that mimics destabilization of biological membranes by protein aggregation despite its heavy involvement in neurodegenerative diseases. In this talk, I will present our recent efforts to provide a giant unilamellar vesicle as a protocell mimicking destabilization of biological membranes by intracellular protein aggregation in a controllable manner. In addition, the intra- and intercellular effects of the protein aggregation to organelle and other cell mimics in a simplified system will be discussed.