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  • 09월 23일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제126회 대한화학회 학술발표회 및 총회 Competition between electrostatic bending and intrinsic rigidity of DNA in binding with a cationic nanoparticle: towards the development of a Brownian motor

등록일
2020년 8월 26일 13시 18분 55초
접수번호
0074
발표코드
PHYS3-1 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
화 15시 : 30분
발표형식
심포지엄
발표분야
Physical Chemistry - Recent Theoretical and Computer Simulation Studies of Macromolecules
저자 및
공동저자
Jun Soo Kim
Department of Chemistry and Nanoscience, Ewha Womans University, Korea

We design a DNA-based Brownian motor for directional transport of positively charged nanoparticles along a single, long double-stranded DNA (dsDNA) with elaborately designed flexibility variation. To prove its realization, we first investigate the bending of intrinsically rigid dsDNA by binding with a cationic nanoparticle, using the coarse-grained molecular dynamics simulations. An electric charge of the nanoparticle and the sequence-dependent flexibility of dsDNA are varied to elucidate the competitive effects of intrinsic rigidity of dsDNA and electrostatic interactions between charged dsDNA and a nanoparticle. We prove that the nanoparticle wrapped around by dsDNA rolls over the dsDNA towards more flexible region of the dsDNA. This work suggests that dsDNA molecules with elaborately designed flexibility variation can be used as a molecule-scale guide for spatial and dynamic control of nanoparticles for future applications.


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