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  • 09월 23일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제126회 대한화학회 학술발표회 및 총회 DNA-mediated Signaling through Redox Chemistry

2020년 8월 28일 13시 52분 25초
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월 11시 : 00분
KCS - Plenary Lecture
저자 및
Jacqueline K. Barton
John G. Kirkwood and Arthur A. Noyes Professor of Chemistry , California Institute of Technology, United States
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승인 1건
Many experiments have now shown that double helical DNA may serve as a conduit for efficient redox chemistry over long molecular distances. This chemistry is exquisitely sensitive to perturbations in the DNA base stack, such as arise with base mismatches, lesions, and protein binding. We have explored how this chemistry may be used within the cell for long range signaling. Increasingly, 4Fe-4S clusters are being found in DNA-binding proteins involved in genome maintenance. These 4Fe-4S clusters, common redox cofactors, are associated not only with repair proteins but also DNA polymerases and primase. Studies are described to characterize DNA–mediated charge transport by these metalloproteins. Experiments indicate that this chemistry is important in the context of oxidative damage and also may provide a first step in how DNA repair proteins may localize in the vicinity of lesions. This redox chemistry at a distance, mediated by the DNA helix, offers a route for long range signaling among DNA-processing proteins across the genome.